New PDF release: Alzheimer’s Disease: Cellular and Molecular Aspects of

By J. Robin Harris (auth.), J. Robin Harris, Falk Fahrenholz (eds.)

ISBN-10: 0387232257

ISBN-13: 9780387232256

ISBN-10: 0387232265

ISBN-13: 9780387232263

This publication incorporates a survey of present-day study into the biomedical basics of Alzheimer’s sickness (AD). It includes 20 chapters facing generally ranging themes, all of that have a bearing upon the knowledge and therapy of advert. beginning with a extensive survey of the contribution that a number of the microscopical ideas (light microscopy, electron microscopy, atomic strength microscopy) have made because the seminal gentle microscopical stories of Alois Alzheimer, the publication provides chapters on professional topics:- transgenic mouse types of advert; the enzymology of amyloid-ß creation and degradation; oxidant tension and antioxidant safety; the involvement of steel ions and the effect of chelators; the significance of amyloid-ß oligomers and fibrils, the function of ldl cholesterol of their formation and attribute binding of the dye Congo crimson; of the various advert plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase obtain person awareness; the influence of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are lined, as are drug interactions, the ß-sheet breaking peptides and the statins which could hinder oligomer/fibril formation in advert; the potential value of amyloid-ß phosphorylation gets particular attention.

Overall, the publication features a large diversity of present info on mobile, biochemical and structural features of amyloid-ß, of direct relevance to Alzheimer’s disease.

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Extra info for Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid β

Sample text

Jung, M. W,, Bang, O. , Kim, S. , 2003, Lovastatin enhances Afi production and senile plaque deposition in female Tg2576 mice. Neurobiol. Aging 24: 637-643. , 2002, Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417: 254-259. , 2003, Neuroimaging and early diagnosis of Alzheimer disease: A look to the future. Radiology 266: 315-336. , 2003, 3-(4-{[benzyl(methyl)amino]methyl}-phenyl)6,7-dimethoxy-2H-2-chromenmone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced B-amyloid aggregation: A dual function lead for Alzheimer's disease therapy.

Neurosci. 24: 4181-4186. Behl, C , 1999, Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches. Prog. Neurobiol. 57: 301-323. , 2002, Antioxidant protetion in Alzheimer's disease as preventive and therapeutic approach. Free Rad. Biol. Med. 33: 182-191. , 2003, Amylid P-protein (AP) assembly: Ap40 and Ap42 oligomerize through distinct pathways. Proc. Natl. Actd. Sci. USA 100: 330-335. , 2001, On the turnover of brain cholesterol in patients with Alzheimer's disease.

2003, Glycation of the amyloid B-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's diseascProc. Natl. Acad. USA 100: 8182-8187. C, 2001, The morphological phenotype of p-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 105: 99-107. , Metal binding and oxidation of amyloid-p within isolated senile plaque cores: Raman microscopic evidence. Biochemistry 42: 2768-2773. , and Butterfield, D. , 2003, Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid P-peptide (1-42) in a transgenic Caenorhabditis elegans model.

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Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid β by J. Robin Harris (auth.), J. Robin Harris, Falk Fahrenholz (eds.)


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